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New Diabetes Drug a Combination of Two Therapies

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At a glance:

Avandaryl, a new combination therapy for type II diabetes is found to lower blood sugar and increase insulin sensitivity better than either treatment alone. 
 
Researchers combined rosiglitazone maleate (Avandia) with glimepiride (Amaryl) and reported results of their study to the American Diabetes Association. 
 
Some improvement in markers for cardiovascular disease was also seen with Avandaryl. 
 
Side effects were consistent with those of the individual medications and included anemia, edema, and weight gain. 
 
Hopes are that the combination therapy will reduce the serious complications of diabetes, including heart, kidney, nerve and vision problems. 
 

New Data Demonstrate Benefits of Initial Use of Avandaryl(R) ...

PR Newswire - 6/11/2006 1:03 AM

WASHINGTON, June 10 /PRNewswire/ -- New research presented today at the 66th Annual Scientific Sessions of the American Diabetes Association (ADA) show the benefits of the initial use of Avandaryl in helping people with type 2 diabetes achieve blood sugar targets and improving insulin sensitivity. These data suggest that treatment of drug-naive people with Avandaryl may be more efficacious than using one therapy alone. Avandaryl is the only therapy available that combines a thiazolidinedione (TZD), rosiglitazone maleate -- separately marketed as Avandia(R) -- with a sulfonylurea, glimepiride -- separately marketed as Amaryl(R) -- to treat type 2 diabetes.
 
"Given the progressive nature of type 2 diabetes, most patients will eventually need more than one therapy to effectively control blood sugar levels over time and reduce their risk of potentially serious diabetes-related complications, such as heart disease and stroke," said Barry Goldstein, M.D., Ph.D., director, Division of Endocrinology, Diabetes and Metabolic Diseases, Jefferson Medical College of Thomas Jefferson University, Philadelphia, and an author of one of the papers. "Using more effective treatment approaches earlier in the course of the disease, including the use of combination medications, is important for the management of type 2 diabetes.
 
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