Therapeutic prospects beyond COX -2 inhibitors -
Selective inhibitors of mPGES-1 may retain much of the benefit of COX -2 inhibitor drugs like Vioxx and Celebrex, while diminishing the risk of heart attack and stroke by having precisely the opposite effect on prostacyclin.
Researchers at the University of Pennsylvania School of Medicine have clarified the mechanism by which drugs like Celebrex and Vioxx cause heart problems, in multiple animal models. The findings offer the prospect of a new generation of anti-inflammatory drugs that bypass this issue, as reported in the April 13 online edition and May print issue of The Journal of Clinical Investigation.
"Although these results are in mice, not people, they raise an exciting possibility which can be tested in humans," says senior author Garret FitzGerald, MD, Director of Penn's Institute for Translational Medicine and Therapeutics.
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