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Leukemia Drug Associated with Infections

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At a glance:

A new study warns doctors that a drug currently used to treat certain types of leukemia and other blood disorders may be associated with more infectious side effects than previously thought. 
 
The drug, Campath (alemtuzumab), was associated with a variety of complications such as herpes infection, toxoplasmosis, progressive multifocal leukoencephalopathy (PML) and other opportunistic and non-opportunistic infections. 
 
While the blood diseases themselves make a patient more prone to infection, the study implies that Campath has an effect on top of that. 
 
Doctors using the drug are urged to be very vigilant when monitoring patients.

Increased Awareness of Alemtuzumab-Related Infections Urged

Cancerpage.com - 7/4/2006 8:07 AM

NEW YORK JUL 03, 2006 (Reuters Health) - The infectious complications arising from the use of alemtuzumab (Campath; Genzyme) for lymphoproliferative disorders may be more diverse than originally appreciated from the previously published trials, clinicians caution in the July 1st issue of Clinical Infectious Diseases.
 
In the paper, Dr. Stanley I. Martin from Ohio State University in Columbus and colleagues report infectious complications associated with alemtuzumab use in 27 patients treated at single institution over a 2.5-year period. Twenty-one of the patients had chronic lymphocytic leukemia (CLL) and six had plasma cell disorders
 
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