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Osteonecrosis of the Jaw (ONJ) News

Multiple Myeloma Patients at Risk for Osteonecrosis of the Jaw

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At a glance:

Multiple myeloma, a type of blood cancer, has been associated with osteonecrosis of the jaw (ONJ), a painful condition involving the breakdown of bone.
 
Risk of ONJ increases with recent history of dental extraction, and may also be related to treamtment with biphosphonates, drugs used to combat multiple myeloma. Zometa and Aredia are two such drugs.
 
Risk of ONJ also increases with age and duration of illness.

Study Describes Osteonecrosis of the Jaw in Patients with Multiple ...

Cancer Consultants (press release) - 2/27/2006 1:30 PM

Osteonecrosis refers to the death of bone. A study published in the Journal of Clinical Oncology reports that risk of osteonecrosis of the jaw (ONJ) in patients with multiple myeloma may increase with age, time since diagnosis of multiple myeloma, long-term use of bisphosphonates, and recent dental extractions.
 
Multiple myeloma is a cancer of plasma cells. Plasma cells are a special type of white blood cell that are part of the body’s immune system. Plasma cells normally live in the bone marrow and make proteins, called antibodies, that circulate in the blood and help fight certain types of infections. Plasma cells also play a role in the maintenance of bone by secretion of a hormone, called osteoclast activating factor, which causes the breakdown of bone.
 
In multiple myeloma, plasma cells infiltrate the bone marrow, spreading into the cavities of all the large bones of the body. As the number of plasma cells increases and greater amounts of proteins are produced, patients experience decreased bone marrow blood cell production, fragility of the bones, pain, and abnormal kidney function. They may also have decreased quantities of normal antibodies necessary to fight certain typ
 
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