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Cancer Risk Associated with Medications for Severe Arthritis

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At a glance:

Medications such as Remicade and Humira, used in threatment of severe rheumatoid arthritis, may increase the patient's risk of some types of cancer and infection. 
 
In one study, by the Mayo Clinic, patients on these drugs showed a threefold increase in cancer risk over patients on a placebo, or one additional case of cancer per 154 patients treated. 
 
Patients in need of medication for severe arthritis should consult with their doctors regarding risks and benefits.

Remicade® and Humira® Increase Risk of Cancer

Cancer Consultants (press release) - 5/18/2006 5:33 PM

According to an article recently published in the Journal of the American Medical Association, patients taking the rheumatoid arthritis drugs Remicade® (infliximab) or Humira® (adalimumab) had a three-fold increased risk of developing various types of cancers.
 
Remicade and Humira are agents referred to as anti-tumor necrosis factor (Anti-TNF) antibodies; they have demonstrated effectiveness in the treatment of severe rheumatoid arthritis. An issue surrounding these agents is that tumor necrosis factor is thought to provide protection against cancer and infection. The use of anti-TNFs that block the productivity of tumor necrosis factor has thus been associated with an increased risk of infection and possibly various types of cancers
 
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