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Obesity Interferes with Hepatitis C Therapy

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Patients with chronic Hepatitis C will respond better to antiviral treatment if they are not obese, a new study finds. 
 
The treatment, a combination of two drugs, only cures about half of patients, and obesity lowers the odds of it working in ways having to do with hormone balance and insulin resistance. Obesity causes a range of metabolic effects which predispose to disease in a variety of organs including the liver. 
 
Researchers recommend that obese patients with Hepatitis C be encourgaed to lose weight and be treated with drugs that increase cellular sensitivity to insulin.

Treating Obesity May Improve The Efficacy Of Therapy For Hepatitis ...

Medical News Today - 6/3/2006 3:07 AM

According to a new study, obese patients chronically infected with the hepatitis C virus (HCV) and treated with combination drug therapy may have better outcomes if the underlying abnormalities caused by excessive fat tissue are corrected. Weight loss, medications to decrease insulin resistance and extending duration or dosage of therapy are strategies that may improve the efficacy of therapy.
 
The results of this study appear in the June 2006 issue of Hepatology, the official journal of the American Association for the Study of Liver Diseases (AASLD). Published by John W
 
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