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Heart Valve Disease News

Heart Valve Damage Resulting from Other Diseases - Process Uncovered

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At a glance:

Lab studies in Wisconsin have shown a link between a variety of diseases and heart valve damage. 
 
Such diseases as lupus and rheumatoid arthritis cause certain cells to shed tiny particles (endothelium derived microparticles) into the blood. 
 
It's these microparticles that, in higher than normal levels, interfere with the cells of the heart valves, inhibiting their growth and their ability to respond to regulatory factors. 
 
The hope is that a greater understanding of the process will lead to prevention and treatment of the damage. 
 
Studies are also underway to determine the effects of microparticles on other parts of the body.

Evidence That Circulating Endothelial Microparticles Lead to Heart ...

Newswise - 4/4/2006 2:50 PM

Newswise — Under normal physiological conditions, low levels of microparticles are continually being shed into the blood from the endothelium – the cells that line the inside of blood vessels and some organs –and appear to cause no problems. But during some diseases, the level of endothelium-derived microparticles circulating in the blood rises. Now, researchers from the Medical College of Wisconsin in Milwaukee and Children’s Research Institute report the first evidence that elevated levels of these microparticles can lead to disease and dysfunction of the heart valves.
 
Dr. Tara Sander presented the study results on April 4 at Experimental Biology 2006 in San Francisco. Dr. Denise Klinkner, a surgical research fellow in Dr. Tara Sander’s laboratory, conducted the study as part of ongoing research in Dr. Sander’s laboratory to understand if abnormally high levels of endothelium-derived microparticles negatively affect the endothelial cells lining the heart valve leaflets, cells that are essential for normal function and repair and that often are injured or become dysfunctional in valve disease
 
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Comments On Heart Valve Disease News Articles:

Cigarette Smoking
Comment On: Heart Valve Damage Resulting from Other Diseases - Process Uncovered
Posted by Waverlyn White on 4/9/2007 | Filed Under: Heart Valve Disease

April 9, 2007 To whom it may concern: I write this letter because both my mother and grandfather, passed away from cigarette smoking. They both smoked for over 15 years, I do not believe there was a surgeon general warning on their pkgs of cigarettes. My mother had cardiovascular disease hardening of the arteries, I recently found out this is linked to cigarette smoking, because I was working on a research paper for school. I also found out that high blood pressure is also linked to cigarette smoking. I also have a son who has been smoking since age 16 yrs old, he is now 33 yrs old, and smoke daily. DOB 8-25-1973 Regards, Waverlyn White 5815 6th Avenue Los Angeles (323) 294-2811


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