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Juvenile Diabetes Research Continues

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Research towards a cure for juvenile diabetes continues, with reports out this month on progress in reversing the disease in mice.
 
The theory is to disrupt the immunological attack that destroys the insulin-producing cells of the pancreas, which is the process leading to type I diabetes.
 
In these studies, spleen cells from healthy mice were transplanted into diseased mice in the hope that they would transform into pancreatic cells and begin to function.

Efforts to Replicate Controversial Diabetes Therapy Bring Partial

Newswise (press release) - 3/23/2006 2:33 PM

An effort by researchers at the University of Chicago to confirm the results of a high-profile study that brought extraordinary hope to diabetes researchers and patients worldwide has met with considerable, but not complete, success. The researchers were able to reverse type-1 diabetes in one-third of mice but were unable to find any evidence of insulin-producing beta cells derived from donated spleen cells, initially thought to be a crucial component of the therapy.
 
"Using a protocol that was identical to the original study, we were able essentially to cure 32 percent of treated mice, which was quite encouraging, even though it was less than the 67- to 92-percent cure rates previously reported," said transplant immunologist Anita Chong, PhD, associate professor of surgery at the University of Chicago and lead author of the study. "We saw no evidence, however, of spleen-derived beta cells in the pancreas, despite using very s
 
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